InChIKey	HEFNNWSXXWATRW-UHFFFAOYSA-N
Compound Name	Ibuprofen, (+-)-
Canonical SMILES	CC(C)Cc1ccc(C(C)C(=O)O)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	6.8
Source	ChEMBL

DrugBank ID	DB01050
Drug Name	Ibuprofen
CAS Number	15687-27-1
Groups	approved investigational
ATC Codes	C01EB16 R02AX02 N02AJ19 M01AE51 G02CC01 M01AE01 M02AA13 N02AJ08 N02AJ23
Description	Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspi...

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Categories: Acids, Carbocyclic Agents causing angioedema Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antiinflammatory Preparations, Non-Steroids for Topical Use Antiinflammatory Products for Vaginal Administration Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Arylpropionic acid NSAIDS COX-1 Inhibitors COX-2 Inhibitors Central Nervous System Agents Cyclooxygenase Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Experimental Unapproved Treatments for COVID-19 Nephrotoxic agents Nervous System Non COX-2 selective NSAIDS OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OATP2B1/SLCO2B1 substrates Other Nonsteroidal Anti-inflammatory Agents P-glycoprotein inhibitors P-glycoprotein substrates Peripheral Nervous System Agents Pharmaceutical Preparations Phenylpropionates Propionates Sensory System Agents Throat Preparations Topical Products for Joint and Muscular Pain UDP Glucuronosyltransferases Inhibitors UGT1A1 Substrates UGT1A3 substrates UGT1A9 Substrates UGT2B17 Inhibitors UGT2B7 substrates

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Cross-references: BindingDB: 50009859 ChEBI: 5855 CHEMBL521 ChemSpider: 3544 Drugs Product Database (DPD): 2609 Guide to Pharmacology: 2713 IUPHAR: 2713 C01588 D00126 PharmGKB: PA449957 PubChem:3672 PubChem:46507255 RxCUI: 5640 Therapeutic Targets Database: DAP000780 Wikipedia: Ibuprofen