Molecule Details
InChIKeyHEAIZQNMNCHNFD-UHFFFAOYSA-N
Compound NameAmg-208
Canonical SMILESCOc1ccc2c(OCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.93
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08079
Drug NameAMG-208
CAS Number1002304-34-8
Groups investigational
ATC Codes nan
DescriptionAMG-208 has been used in trials studying the treatment of Cancer, Tumors, Oncology, Prostate Cancer, and Oncology Patients, among others.
Cross-references: BindingDB: 24470 ChEBI: 90626 CHEMBL496102 ChemSpider: 21486186 PDB: L5G PubChem:24864821 PubChem:99444550 ZINC: ZINC000034285235
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P22612 PRKACG Homo sapiens Human PF00069 8.7 Kd ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 8.1 IC50 ChEMBL;BindingDB
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 7.0 IC50 BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P08581 MET Hepatocyte growth factor receptor inhibitor targets