Molecule Details
InChIKeyHDXDQPRPFRKGKZ-INIZCTEOSA-N
Canonical SMILESCC[C@H](Nc1ncnc2[nH]cnc12)c1oc2ccccc2c(=O)c1-c1cccc(F)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.54
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB15295
Drug NameTenalisib
CAS Number1639417-53-0
Groups investigational
ATC Codes nan
DescriptionTenalisib is under investigation in clinical trial NCT03711604 (Compassionate Use Study of Tenalisib (RP6530)).
Categories: Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Phosphoinositide-3 Kinase Inhibitors Pyrans
Cross-references: BindingDB: 50512870 CHEMBL4297584 ChemSpider: 52083673
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
O00329 PIK3CD Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 7.6 IC50 ChEMBL;BindingDB
P48736 PIK3CG Homo sapiens Human PF00454 PF00792 PF00794 PF00613 PF19710 7.5 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform inhibitor targets