InChIKey	HDHDTKMUACZDAA-PHNIDTBTSA-N
Compound Name	Setmelanotide
Canonical SMILES	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)NC1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	8.2
Source	ChEMBL;BindingDB

DrugBank ID	DB11700
Drug Name	Setmelanotide
CAS Number	920014-72-8
Groups	approved investigational
ATC Codes	A08AA12
Description	Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies.[L24474] It is an agonist of the melanocortin 4 receptor.[A224449] Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, b...

---

Categories: Alimentary Tract and Metabolism Amino Acids, Peptides, and Proteins Anti-Obesity Agents Antiobesity Preparations, Excl. Diet Products Centrally Acting Antiobesity Products Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hypothalamic Hormones Melanocortin 4 Receptor Agonist Melanocortin 4 Receptor Agonists Melanocortins Melanocyte-Stimulating Hormones Nerve Tissue Proteins Neuropeptides Peptide Hormones Peptides Pituitary Hormones Pituitary Hormones, Anterior Pro-Opiomelanocortin Protein Precursors Proteins Receptor, Melanocortin, Type 4, agonists

---

Cross-references: BindingDB: 50581319 CHEMBL3301624 ChemSpider: 10166169 Drugs Product Database (DPD): 23838 PubChem:11993702 PubChem:347828065 RxCUI: 2469247 Wikipedia: Setmelanotide