InChIKey	HCYAFALTSJYZDH-UHFFFAOYSA-N
Compound Name	Desipramine
Canonical SMILES	CNCCCN1c2ccccc2CCc2ccccc21
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	14
Pfam Stratification	Cross-Family
Avg pChEMBL	7.22
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB01151
Drug Name	Desipramine
CAS Number	50-47-5
Groups	approved
ATC Codes	N06AA01
Description	Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal...

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Categories: Adrenergic Agents Adrenergic Uptake Inhibitors Agents producing tachycardia Agents that produce hypertension Agents that reduce seizure threshold Anticholinergic Agents Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Tricyclic Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Inhibitors (weak) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dibenzazepines Drugs that are Mainly Renally Excreted Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Histamine Antagonists Histamine H1 Antagonists Membrane Transport Modulators Muscarinic Antagonists Narrow Therapeutic Index Drugs Nervous System Neurotoxic agents Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Non-Selective Monoamine Reuptake Inhibitors OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inhibitors Potential QTc-Prolonging Agents Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin Agents Serotonin Modulators Serotonin Receptor Antagonists Tricyclics and Other Norepinephrine-reuptake Inhibitors

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Cross-references: BindingDB: 35229 ChEBI: 47781 CHEMBL72 ChemSpider: 2888 Drugs Product Database (DPD): 10024 Guide to Pharmacology: 2399 IUPHAR: 2399 C06943 D07791 PDB: DSM PharmGKB: PA449233 PubChem:2995 PubChem:46504624 RxCUI: 3247 Therapeutic Targets Database: DAP001151 Wikipedia: Desipramine ZINC: ZINC000001530611