InChIKey	HBNPJJILLOYFJU-VMPREFPWSA-N
Compound Name	Mibefradil
Canonical SMILES	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	21
Pfam Stratification	Cross-Family
Avg pChEMBL	6.29
Source	ChEMBL;BindingDB

DrugBank ID	DB01388
Drug Name	Mibefradil
CAS Number	116644-53-2
Groups	approved investigational withdrawn
ATC Codes	C08CX01
Description	Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.

---

Categories: Agents causing hyperkalemia Antiarrhythmic agents Antihypertensive Agents Benzimidazoles Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Membrane Transport Modulators Moderate Risk QTc-Prolonging Agents Naphthalenes P-glycoprotein inhibitors P-glycoprotein substrates QTc Prolonging Agents Selective Calcium Channel Blockers With Mainly Vascular Effects Tetrahydronaphthalenes Vasodilating Agents

---

Cross-references: BindingDB: 78934 ChEBI: 6920 CHEMBL45816 ChemSpider: 54673 C07222 PDB: MWV PharmGKB: PA450492 PubChem:60663 PubChem:46504498 RxCUI: 83213 Therapeutic Targets Database: DCL000341 Wikipedia: Mibefradil ZINC: ZINC000003782486