Molecule Details
InChIKeyGYKZZSDJTVJBHL-UHFFFAOYSA-N
Compound Name6-(2-methoxy-4-hydroxyphenyl)-3-1H-benzoimidazol-2-yl-1H-indazole
Canonical SMILESCOc1cc(O)ccc1-c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.5
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.3 IC50 ChEMBL;BindingDB
P23458 JAK1 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.2 IC50 ChEMBL;BindingDB
P11802 CDK4 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P24385 CCND1 Homo sapiens Human PF02984 PF00134 7.8 Ki ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 7.8 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.4 IC50 ChEMBL;BindingDB
O14757 CHEK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 7.1 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.0 IC50 ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Ki ChEMBL