InChIKey	GXPHKUHSUJUWKP-UHFFFAOYSA-N
Compound Name	Troglitazone
Canonical SMILES	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	6.46
Source	ChEMBL

DrugBank ID	DB00197
Drug Name	Troglitazone
CAS Number	97322-87-7
Groups	approved withdrawn
ATC Codes	A10BG01
Description	Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].

---

Categories: Alimentary Tract and Metabolism BSEP/ABCB11 Inhibitors Benzopyrans Blood Glucose Lowering Agents Chromans Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs Used in Diabetes Heterocyclic Compounds, Fused-Ring OATP1B1/SLCO1B1 Inhibitors Oral Hypoglycemics Pyrans Sulfur Compounds Thiazoles Thiazolidinediones UGT1A1 Substrates UGT1A3 substrates UGT1A4 substrates UGT1A6 Inhibitors UGT1A6 substrate UGT1A9 Substrates UGT2B7 substrates

---

Cross-references: BindingDB: 50088494 ChEBI: 9753 CHEMBL408 ChemSpider: 5389 Guide to Pharmacology: 2693 IUPHAR: 2693 D00395 PharmGKB: PA451799 PubChem:5591 PubChem:46504655 RxCUI: 72610 Therapeutic Targets Database: DAP001337 Wikipedia: Troglitazone