InChIKey	GXJABQQUPOEUTA-RDJZCZTQSA-N
Compound Name	Bortezomib
Canonical SMILES	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	47
Pfam Stratification	Cross-Family
Avg pChEMBL	7.85
Source	ChEMBL;BindingDB

DrugBank ID	DB00188
Drug Name	Bortezomib
CAS Number	179324-69-7
Groups	approved investigational
ATC Codes	L01XG01
Description	Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma.[A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, ...

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Categories: Acids Acids, Noncarboxylic Antineoplastic Agents Antineoplastic and Immunomodulating Agents Boron Compounds Boronic Acids Cardiotoxic antineoplastic agents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (moderate) Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hepatotoxic Agents Hypotensive Agents Immunosuppressive Agents Myelosuppressive Agents Narrow Therapeutic Index Drugs OATP1B3 inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Potential QTc-Prolonging Agents Proteasome Inhibitors Pyrazines QTc Prolonging Agents

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Cross-references: BindingDB: 50069989 ChEBI: 52717 CHEMBL325041 ChemSpider: 343402 Drugs Product Database (DPD): 13053 D03150 PDB: BO2 PharmGKB: PA10252 PubChem:387447 PubChem:46508736 RxCUI: 358258 Therapeutic Targets Database: DAP001318 Wikipedia: Bortezomib ZINC: ZINC000169746649