N-[[4-[[5-bromo-4-[[(2R)-3-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]phenyl]-oxo-(2-oxoethyl)-lambda6-sulfanylidene]-2-trimethylsilylethanesulfonamide

InChIKey	`GUQGZGWZZNIUIH-LXAPUOBYSA-N`
Compound Name	N-[[4-[[5-bromo-4-[[(2R)-3-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]phenyl]-oxo-(2-oxoethyl)-lambda6-sulfanylidene]-2-trimethylsilylethanesulfonamide
Canonical SMILES	`C[C@@H](Nc1nc(Nc2ccc(S(=O)(CC=O)=NS(=O)(=O)CC[Si](C)(C)C)cc2)ncc1Br)C(C)(C)O`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.97
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P24941	CDK2	Homo sapiens	Human	PF00069	7.3	IC50	ChEMBL;BindingDB
P06493	CDK1	Homo sapiens	Human	PF00069	6.8	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.8	IC50	ChEMBL;BindingDB