5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-[5-(4-methylpiperazin-1-yl)-2-pyridinyl]pyrimidin-2-amine

InChIKey	`GULUZCYKKDJDGN-UHFFFAOYSA-N`
Compound Name	5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indole]-5'-yl)-N-[5-(4-methylpiperazin-1-yl)-2-pyridinyl]pyrimidin-2-amine
Canonical SMILES	`CC1=Nc2c(F)cc(-c3nc(Nc4ccc(N5CCN(C)CC5)cn4)ncc3F)cc2C12CCCC2`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.91
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P06493	CDK1	Homo sapiens	Human	PF00069	9.6	IC50	ChEMBL;BindingDB
P30281	CCND3	Homo sapiens	Human	PF02984 PF00134	7.1	IC50	ChEMBL
Q00534	CDK6	Homo sapiens	Human	PF00069	7.1	IC50	ChEMBL;BindingDB