InChIKey	GUGOEEXESWIERI-UHFFFAOYSA-N
Compound Name	Terfenadine
Canonical SMILES	CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	6.53
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00342
Drug Name	Terfenadine
CAS Number	50679-08-8
Groups	approved withdrawn
ATC Codes	R06AX12
Description	In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.

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Categories: Anticholinergic Agents Antihistamines for Systemic Use BSEP/ABCB11 Substrates Benzene Derivatives Benzhydryl Compounds Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Inhibitors (weak) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strong) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates (strength unknown) Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Highest Risk QTc-Prolonging Agents Histamine Agents Histamine Antagonists Histamine H1 Antagonists Histamine H1 Antagonists, Non-Sedating Muscarinic Antagonists Neurotransmitter Agents P-glycoprotein inhibitors P-glycoprotein substrates Piperidines QTc Prolonging Agents

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Cross-references: BindingDB: 50017376 ChEBI: 9453 CHEMBL17157 ChemSpider: 5212 Drugs Product Database (DPD): 1918 Guide to Pharmacology: 2608 IUPHAR: 2608 C07463 D00521 PharmGKB: PA451619 PubChem:5405 PubChem:46507007 RxCUI: 42330 Therapeutic Targets Database: DAP000102 Wikipedia: Terfenadine