Molecule Details
InChIKeyGQHMZZXJWGPHDA-UHFFFAOYSA-N
Compound Name3-(Pyridin-4-ylamino)-4-[[3-(trifluoromethyl)phenyl]methylamino]cyclobut-3-ene-1,2-dione
Canonical SMILESO=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)20
Pfam Stratification Cross-Family
Avg pChEMBL6.49
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (20)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 7.5 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.3 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.1 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.0 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 6.6 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.4 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.3 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.3 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.3 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 6.3 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.1 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.0 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.0 Ki ChEMBL