Molecule Details
| InChIKey | GPMXUUPHFNMNDH-UHFFFAOYSA-N |
|---|---|
| Compound Name | Trifluperidol |
| Canonical SMILES | O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.11 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13552 |
|---|---|
| Drug Name | Trifluperidol |
| CAS Number | 749-13-3 |
| Groups | experimental |
| ATC Codes | N05AD02 |
| Description | nan |
Categories: Antipsychotic Agents Butyrophenone Derivatives Butyrophenones Central Nervous System Agents Central Nervous System Depressants Dopamine Agents Dopamine Antagonists Ketones Nervous System Neurotoxic agents Neurotransmitter Agents Psycholeptics Psychotropic Drugs Tranquilizing Agents
Cross-references: BindingDB: 50047016 ChEBI: 135662 CHEMBL15023 ChemSpider: 5366 RxCUI: 10804 Wikipedia: Trifluperidol ZINC: ZINC000000538505
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 9.1 | Ki | ChEMBL;BindingDB |
| Q15125 | EBP | Homo sapiens | Human | PF05241 | 6.8 | Ki | ChEMBL;BindingDB |
| P10635 | CYP2D6 | Homo sapiens | Human | PF00067 | 6.8 | Ki | ChEMBL;BindingDB |
| P32352 | ERG2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Pathogen | PF04622 | 9.8 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P23946 | CMA1 | Chymase | modulator | targets |