Molecule Details
InChIKeyGOEMGAFJFRBGGG-UHFFFAOYSA-N
Compound NameAcebutolol
Canonical SMILESCCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(C(C)=O)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL6.23
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01193
Drug NameAcebutolol
CAS Number37517-30-9
Groups approved investigational
ATC Codes C07AB04 C07BB04
DescriptionA cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.

Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Antagonists Agents causing hyperkalemia Alcohols Amines Amino Alcohols Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Autonomic Agents Beta Blocking Agents and Thiazides Beta Blocking Agents, Selective Beta Blocking Agents, Selective, and Thiazides Beta-Blockers (Beta1 Selective) Bradycardia-Causing Agents Cardiovascular Agents Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hypotensive Agents Neurotransmitter Agents P-glycoprotein substrates Peripheral Nervous System Agents Phenoxypropanolamines Propanolamines Propanols QTc Prolonging Agents Sympathomimetics
Cross-references: BindingDB: 25755 ChEBI: 2379 CHEMBL642 ChemSpider: 1901 Drugs Product Database (DPD): 11162 C06803 D02338 PharmGKB: PA448011 PubChem:1978 PubChem:46509113 RxCUI: 149 Therapeutic Targets Database: DAP000484 Wikipedia: Acebutolol
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P08588 ADRB1 Homo sapiens Human PF00001 6.4 IC50 ChEMBL;BindingDB
P07550 ADRB2 Homo sapiens Human PF00001 6.1 Kd BindingDB
DrugBank Target Actions (5)
Target Gene Target Name Action Type
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P07550 ADRB2 Beta-2 adrenergic receptor partial agonist targets
P08588 ADRB1 Beta-1 adrenergic receptor partial agonist targets
P08183 ABCB1 ATP-dependent translocase ABCB1 substrate transporters