Molecule Details
| InChIKey | GOEMGAFJFRBGGG-UHFFFAOYSA-N |
|---|---|
| Compound Name | Acebutolol |
| Canonical SMILES | CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(C(C)=O)c1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.23 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01193 |
|---|---|
| Drug Name | Acebutolol |
| CAS Number | 37517-30-9 |
| Groups | approved investigational |
| ATC Codes | C07AB04 C07BB04 |
| Description | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. |
Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic beta-1 Receptor Antagonists Adrenergic beta-Antagonists Agents causing hyperkalemia Alcohols Amines Amino Alcohols Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Autonomic Agents Beta Blocking Agents and Thiazides Beta Blocking Agents, Selective Beta Blocking Agents, Selective, and Thiazides Beta-Blockers (Beta1 Selective) Bradycardia-Causing Agents Cardiovascular Agents Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Hypotensive Agents Neurotransmitter Agents P-glycoprotein substrates Peripheral Nervous System Agents Phenoxypropanolamines Propanolamines Propanols QTc Prolonging Agents Sympathomimetics
Cross-references: BindingDB: 25755 ChEBI: 2379 CHEMBL642 ChemSpider: 1901 Drugs Product Database (DPD): 11162 C06803 D02338 PharmGKB: PA448011 PubChem:1978 PubChem:46509113 RxCUI: 149 Therapeutic Targets Database: DAP000484 Wikipedia: Acebutolol
Target Activities (2)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P10635 | CYP2D6 | Cytochrome P450 2D6 | inhibitor | enzymes |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| P07550 | ADRB2 | Beta-2 adrenergic receptor | partial agonist | targets |
| P08588 | ADRB1 | Beta-1 adrenergic receptor | partial agonist | targets |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | substrate | transporters |