4-N-(2,5-dichlorophenyl)-2-N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}pyrimidine-2,4-diamine

InChIKey	`GNLAGGCSJGJECE-UHFFFAOYSA-N`
Compound Name	4-N-(2,5-dichlorophenyl)-2-N-{4-[3-(dimethylamino)-2-hydroxypropoxy]phenyl}pyrimidine-2,4-diamine
Canonical SMILES	`CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cc(Cl)ccc3Cl)n2)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	19
Pfam Stratification	Cross-Family
Avg pChEMBL	6.43
Source	ChEMBL;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q04771	ACVR1	Homo sapiens	Human	PF01064 PF07714 PF08515	7.3	Ki	ChEMBL
P29376	LTK	Homo sapiens	Human	PF12810 PF07714	7.1	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.9	Ki	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.7	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.7	Ki	ChEMBL
P45983	MAPK8	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
Q07912	TNK2	Homo sapiens	Human	PF09027 PF11555 PF07714 PF22931 PF14604	6.6	Ki	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	6.5	Ki	ChEMBL
Q7L7X3	TAOK1	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
P09619	PDGFRB	Homo sapiens	Human	PF00047 PF13927 PF25305 PF07714	6.4	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.3	Ki	ChEMBL
P50750	CDK9	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P11802	CDK4	Homo sapiens	Human	PF00069	6.1	IC50	ChEMBL
Q05397	PTK2	Homo sapiens	Human	PF21477 PF00373 PF18038 PF03623 PF07714	6.1	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.0	Ki	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	6.0	pIC50	TTD_MultiTarget
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	6.0	Ki	ChEMBL
Q9UM73	ALK	Homo sapiens	Human	PF12810 PF00629 PF07714	6.0	Ki	ChEMBL