Molecule Details
InChIKeyGMVQPWCWWLPOQT-FQEVSTJZSA-N
Compound Name(S)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide
Canonical SMILESCN(C)[C@H]1CCCN(c2ccc(C(F)(F)F)cc2NC(=O)c2cc(C#Cc3cnc(N)nc3)ccc2F)C1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 8.3 IC50 ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.8 IC50 ChEMBL
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 7.4 IC50 ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.9 IC50 ChEMBL;BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.8 IC50 ChEMBL
P54760 EPHB4 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.5 IC50 ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 IC50 ChEMBL
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.3 pIC50 TTD_MultiTarget
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.0 IC50 ChEMBL