Molecule Details
InChIKeyGMQQMSKNSNVPOW-VOTSOKGWSA-N
Compound Name4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
Canonical SMILESCc1c(Nc2c(C#N)cncc2/C=C/c2cccc(S(=O)(=O)N3CCN(C)CC3)c2)ccc2[nH]ccc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)9
Pfam Stratification Cross-Family
Avg pChEMBL7.43
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (9)
Target Gene Organism Category Pfam pChEMBL Type Source
Q04759 PRKCQ Homo sapiens Human PF00130 PF21494 PF00069 PF00433 9.3 IC50 ChEMBL;BindingDB
Q02156 PRKCE Homo sapiens Human PF00130 PF00168 PF00069 PF00433 8.8 IC50 ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 7.7 pIC50 TTD_MultiTarget
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.7 IC50 ChEMBL;BindingDB
P24723 PRKCH Homo sapiens Human PF00130 PF00168 PF00069 PF00433 7.0 IC50 ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.8 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.7 IC50 ChEMBL;BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 6.3 IC50 ChEMBL;BindingDB