3-[5-(1H-Imidazol-1-YL)-7-methyl-1H-benzimidazol-2-YL]-4-[(pyridin-2-ylmethyl)amino]pyridin-2(1H)-one — MultiTargetDB

Molecule Details

InChIKey	`GLTRPHMPCVLOJS-UHFFFAOYSA-N`
Compound Name	3-[5-(1H-Imidazol-1-YL)-7-methyl-1H-benzimidazol-2-YL]-4-[(pyridin-2-ylmethyl)amino]pyridin-2(1H)-one
Canonical SMILES	`Cc1cc(-n2ccnc2)cc2nc(-c3c(NCc4ccccn4)cc[nH]c3=O)[nH]c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	6.84
Source	ChEMBL;BindingDB

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB07474
Drug Name	3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 50206120 CHEMBL397666 ChemSpider: 10758011 PDB: BMI PubChem:22021390 PubChem:99443945 ZINC: ZINC000016052301

Target Activities (3)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P08684	CYP3A4	Homo sapiens	Human	PF00067	7.1	IC50	ChEMBL;BindingDB
P33261	CYP2C19	Homo sapiens	Human	PF00067	7.0	IC50	ChEMBL
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	6.4	IC50	ChEMBL;BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
P08069	IGF1R	Insulin-like growth factor 1 receptor	binder	targets