Molecule Details
InChIKeyGLDSKRNGVVYJAB-DQSJHHFOSA-N
Canonical SMILESCCS(=O)(=O)Nc1ccc2c(c1)/C(=C(/Nc1ccc(CN3CCCCC3)cc1)c1ccccc1)C(=O)N2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)16
Pfam Stratification Cross-Family
Avg pChEMBL7.29
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (16)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9P289 STK26 Homo sapiens Human PF20929 PF00069 8.2 IC50 ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 8.0 Kd ChEMBL
Q9Y6E0 STK24 Homo sapiens Human PF20929 PF00069 8.0 IC50 ChEMBL
O14965 AURKA Homo sapiens Human PF00069 8.0 IC50 ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 7.7 Kd ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 7.5 Kd ChEMBL
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.5 Kd ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 7.3 Kd ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 Kd ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 7.1 Kd ChEMBL
Q8IWQ3 BRSK2 Homo sapiens Human PF21122 PF00069 PF21115 7.0 Kd ChEMBL
O75676 RPS6KA4 Homo sapiens Human PF00069 PF00433 7.0 Kd ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.8 Kd ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.7 IC50 ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 6.6 IC50 ChEMBL
O75460 ERN1 Homo sapiens Human PF00069 PF06479 6.1 IC50 BindingDB