Molecule Details
InChIKeyGKTQBPYMIGXPKG-JVVVGQRLSA-N
Compound Name[O-methyl-11C]2-{4-[4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione
Canonical SMILESCn1c(=O)cnn(CCCCN2CCN(c3cccc4ccc(O[11CH3])cc34)CC2)c1=O
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL7.14
SourceChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
P08908 HTR1A Homo sapiens Human PF00001 8.9 Ki ChEMBL
P21917 DRD4 Homo sapiens Human PF00001 8.1 Ki ChEMBL
P34969 HTR7 Homo sapiens Human PF00001 8.0 Ki ChEMBL
P14416 DRD2 Homo sapiens Human PF00001 7.7 Ki ChEMBL
P18825 ADRA2C Homo sapiens Human PF00001 7.6 Ki ChEMBL
P25100 ADRA1D Homo sapiens Human PF00001 7.5 Ki ChEMBL
P35348 ADRA1A Homo sapiens Human PF00001 7.5 pIC50 TTD_MultiTarget
P35368 ADRA1B Homo sapiens Human PF00001 7.5 Ki ChEMBL
P28223 HTR2A Homo sapiens Human PF00001 7.4 Ki ChEMBL
P07550 ADRB2 Homo sapiens Human PF00001 7.2 Ki ChEMBL
P35462 DRD3 Homo sapiens Human PF00001 7.2 Ki ChEMBL
P28335 HTR2C Homo sapiens Human PF00001 7.0 Ki ChEMBL
P50406 HTR6 Homo sapiens Human PF00001 6.9 Ki ChEMBL
P35367 HRH1 Homo sapiens Human PF00001 6.8 Ki ChEMBL
P47898 HTR5A Homo sapiens Human PF00001 6.6 Ki ChEMBL
P25021 HRH2 Homo sapiens Human PF00001 6.5 Ki ChEMBL
P18089 ADRA2B Homo sapiens Human PF00001 6.5 Ki ChEMBL
Q01959 SLC6A3 Homo sapiens Human PF00209 6.4 Ki ChEMBL
P08588 ADRB1 Homo sapiens Human PF00001 6.3 Ki ChEMBL
Q99720 SIGMAR1 Homo sapiens Human PF04622 6.3 Ki ChEMBL
P08913 ADRA2A Homo sapiens Human PF00001 6.0 Ki ChEMBL