Molecule Details
| InChIKey | GKNRLFKBMBYKNY-IPXWJDOSSA-N |
|---|---|
| Compound Name | (R,E)-1-(3-(1-(prop-1-en-1-ylsulfonyl)azetidin-3-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)ethane-1,2-diol |
| Canonical SMILES | C/C=C/S(=O)(=O)N1CC(c2nn(-c3ccc(OC(F)(F)F)cc3)c3nccc([C@@H](O)CO)c23)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.4 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q15561 | TEAD4 | Homo sapiens | Human | PF01285 PF17725 | 8.2 | IC50 | BindingDB |
| Q15562 | TEAD2 | Homo sapiens | Human | PF01285 PF17725 | 8.0 | IC50 | BindingDB |
| P28347 | TEAD1 | Homo sapiens | Human | PF01285 PF17725 | 7.4 | IC50 | BindingDB |
| Q99594 | TEAD3 | Homo sapiens | Human | PF01285 PF17725 | 6.0 | IC50 | BindingDB |