Molecule Details
| InChIKey | GKJCVYLDJWTWQU-CXLRFSCWSA-N |
|---|---|
| Compound Name | Ly-2874455 |
| Canonical SMILES | C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 6 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.36 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13022 |
|---|---|
| Drug Name | LY-2874455 |
| CAS Number | 1254473-64-7 |
| Groups | investigational |
| ATC Codes | nan |
| Description | LY2874455 has been used in trials studying the treatment of Advanced Cancer. |
Categories: Heterocyclic Compounds, Fused-Ring Pyrazoles Receptors, Fibroblast Growth Factor, antagonists & inhibitors
Cross-references: BindingDB: 50189781 CHEMBL3828009 ChemSpider: 28189058 PDB: 6LF PubChem:46944259 PubChem:347829156 ZINC: ZINC000073069242
Target Activities (6)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 8.9 | IC50 | ChEMBL;BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 8.6 | IC50 | ChEMBL;BindingDB |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 8.2 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 8.2 | IC50 | ChEMBL;BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 8.2 | IC50 | ChEMBL;BindingDB |
| P41212 | ETV6 | Homo sapiens | Human | PF00178 PF02198 | 8.1 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | modulator | targets |