Molecule Details
InChIKeyGKDRMWXFWHEQQT-UHFFFAOYSA-N
Compound NameFostamatinib
Canonical SMILESCOc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL6.83
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12010
Drug NameFostamatinib
CAS Number901119-35-5
Groups approved investigational
ATC Codes B02BX09
DescriptionFostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, L52150]. Fostamatinib has also been granted orphan drug status by the FDA...
Categories: Amines BCRP/ABCG2 Inhibitors Blood and Blood Forming Organs Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Experimental Unapproved Treatments for COVID-19 Hemostatics Kinase Inhibitor Oxazines Phosphodiesterase 5 Inhibitors Pyridines Tyrosine Kinase Inhibitors UGT1A1 Inhibitors UGT1A9 Substrates Vasodilating Agents
Cross-references: BindingDB: 50431381 CHEMBL2103830 ChemSpider: 9846198 Drugs Product Database (DPD): 23528 PDB: 2RC PubChem:11671467 PubChem:347828328 RxCUI: 2044896 Wikipedia: Fostamatinib ZINC: ZINC000043131420
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P43405 SYK Homo sapiens Human PF07714 PF00017 7.5 IC50 ChEMBL;BindingDB
Q8TD19 NEK9 Homo sapiens Human PF00069 PF25390 7.4 Kd ChEMBL
Q9UNQ0 ABCG2 Homo sapiens Human PF01061 PF19055 PF00005 7.3 IC50 ChEMBL;BindingDB
Q13470 TNK1 Homo sapiens Human PF07714 PF22931 6.8 Kd ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Kd ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.2 Kd ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.1 Kd ChEMBL
DrugBank Target Actions (304)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
O60656 O60656 UDP-glucuronosyltransferase 1A9 substrate enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P0DMS8 ADORA3 Adenosine receptor A3 antagonist targets
O00238 BMPR1B Bone morphogenetic protein receptor type-1B inhibitor targets
O00329 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform inhibitor targets
O00444 PLK4 Serine/threonine-protein kinase PLK4 inhibitor targets
O00519 FAAH Fatty-acid amide hydrolase 1 inhibitor targets
O00750 PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta inhibitor targets
O14578 CIT Citron Rho-interacting kinase inhibitor targets
O14730 RIOK3 Serine/threonine-protein kinase RIO3 inhibitor targets
O14757 CHEK1 Serine/threonine-protein kinase Chk1 inhibitor targets
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta inhibitor targets
O14936 CASK Peripheral plasma membrane protein CASK inhibitor targets
O14965 AURKA Aurora kinase A inhibitor targets
O14976 GAK Cyclin-G-associated kinase inhibitor targets
O15075 DCLK1 Serine/threonine-protein kinase DCLK1 inhibitor targets
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase inhibitor targets
O15197 EPHB6 Ephrin type-B receptor 6 inhibitor targets
O15264 MAPK13 Mitogen-activated protein kinase 13 inhibitor targets
O15530 PDPK1 3-phosphoinositide-dependent protein kinase 1 inhibitor targets
O43283 MAP3K13 Mitogen-activated protein kinase kinase kinase 13 inhibitor targets
O43293 DAPK3 Death-associated protein kinase 3 inhibitor targets
O43353 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 inhibitor targets
O60285 NUAK1 NUAK family SNF1-like kinase 1 inhibitor targets
O60674 JAK2 Tyrosine-protein kinase JAK2 inhibitor targets
O75116 ROCK2 Rho-associated protein kinase 2 inhibitor targets
O75385 ULK1 Serine/threonine-protein kinase ULK1 inhibitor targets
O75460 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 inhibitor targets
O75716 STK16 Serine/threonine-protein kinase 16 inhibitor targets
O75747 PIK3C2G Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma inhibitor targets
O75914 PAK3 Serine/threonine-protein kinase PAK 3 inhibitor targets
O76074 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor targets
O94768 STK17B Serine/threonine-protein kinase 17B inhibitor targets
O94804 STK10 Serine/threonine-protein kinase 10 inhibitor targets
O95382 MAP3K6 Mitogen-activated protein kinase kinase kinase 6 inhibitor targets
O95747 OXSR1 Serine/threonine-protein kinase OSR1 inhibitor targets
O95819 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 inhibitor targets
O95835 LATS1 Serine/threonine-protein kinase LATS1 inhibitor targets
O96013 PAK4 Serine/threonine-protein kinase PAK 4 inhibitor targets
O96017 CHEK2 Serine/threonine-protein kinase Chk2 inhibitor targets
P00519 ABL1 Tyrosine-protein kinase ABL1 inhibitor targets
P00533 EGFR Epidermal growth factor receptor inhibitor targets
P04049 RAF1 RAF proto-oncogene serine/threonine-protein kinase inhibitor targets
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 inhibitor targets
P04629 NTRK1 High affinity nerve growth factor receptor inhibitor targets
P05129 PRKCG Protein kinase C gamma type inhibitor targets
P06213 INSR Insulin receptor inhibitor targets
P06239 LCK Tyrosine-protein kinase Lck inhibitor targets
P06241 FYN Tyrosine-protein kinase Fyn inhibitor targets
P06493 CDK1 Cyclin-dependent kinase 1 inhibitor targets
P07332 FES Tyrosine-protein kinase Fes/Fps inhibitor targets
P07333 CSF1R Macrophage colony-stimulating factor 1 receptor inhibitor targets
P07498 P07498 Kappa-casein inhibitor targets
P07711 CTSL Procathepsin L inhibitor targets
P07947 YES1 Tyrosine-protein kinase Yes inhibitor targets
P07948 LYN Tyrosine-protein kinase Lyn inhibitor targets
P07949 RET Proto-oncogene tyrosine-protein kinase receptor Ret inhibitor targets
P08581 MET Hepatocyte growth factor receptor inhibitor targets
P08631 HCK Tyrosine-protein kinase HCK inhibitor targets
P08922 ROS1 Proto-oncogene tyrosine-protein kinase ROS inhibitor targets
P09619 PDGFRB Platelet-derived growth factor receptor beta inhibitor targets
P09769 FGR Tyrosine-protein kinase Fgr inhibitor targets
P09917 ALOX5 Polyunsaturated fatty acid 5-lipoxygenase inhibitor targets
P0C264 SBK3 Uncharacterized serine/threonine-protein kinase SBK3 inhibitor targets
P10721 KIT Mast/stem cell growth factor receptor Kit inhibitor targets
P11309 PIM1 Serine/threonine-protein kinase pim-1 inhibitor targets
P11362 FGFR1 Fibroblast growth factor receptor 1 inhibitor targets
P11802 CDK4 Cyclin-dependent kinase 4 inhibitor targets
P12931 SRC Proto-oncogene tyrosine-protein kinase Src inhibitor targets
P14616 INSRR Insulin receptor-related protein inhibitor targets
P15056 BRAF Serine/threonine-protein kinase B-raf inhibitor targets
P16234 PDGFRA Platelet-derived growth factor receptor alpha inhibitor targets
P16591 FER Tyrosine-protein kinase Fer inhibitor targets
P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha inhibitor targets
P17948 FLT1 Vascular endothelial growth factor receptor 1 inhibitor targets
P19525 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase inhibitor targets
P19784 CSNK2A2 Casein kinase II subunit alpha' inhibitor targets
P21709 EPHA1 Ephrin type-A receptor 1 inhibitor targets
P21802 FGFR2 Fibroblast growth factor receptor 2 inhibitor targets
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 inhibitor targets
P22607 FGFR3 Fibroblast growth factor receptor 3 inhibitor targets
P22694 PRKACB cAMP-dependent protein kinase catalytic subunit beta inhibitor targets
P23458 JAK1 Tyrosine-protein kinase JAK1 inhibitor targets
P25774 CTSS Cathepsin S inhibitor targets
P27448 MARK3 MAP/microtubule affinity-regulating kinase 3 inhibitor targets
P29317 EPHA2 Ephrin type-A receptor 2 inhibitor targets
P29320 EPHA3 Ephrin type-A receptor 3 inhibitor targets
P29322 EPHA8 Ephrin type-A receptor 8 inhibitor targets
P29323 EPHB2 Ephrin type-B receptor 2 inhibitor targets
P29376 LTK Leukocyte tyrosine kinase receptor inhibitor targets
P29597 TYK2 Non-receptor tyrosine-protein kinase TYK2 inhibitor targets
P30291 WEE1 Wee1-like protein kinase inhibitor targets
P30530 AXL Tyrosine-protein kinase receptor UFO inhibitor targets
P31152 MAPK4 Mitogen-activated protein kinase 4 inhibitor targets
P33981 TTK Dual specificity protein kinase TTK inhibitor targets
P35590 TIE1 Tyrosine-protein kinase receptor Tie-1 inhibitor targets
P35916 FLT4 Vascular endothelial growth factor receptor 3 inhibitor targets
P35968 KDR Vascular endothelial growth factor receptor 2 inhibitor targets
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 inhibitor targets
P36888 FLT3 Receptor-type tyrosine-protein kinase FLT3 inhibitor targets
P36896 ACVR1B Activin receptor type-1B inhibitor targets
P36897 TGFBR1 TGF-beta receptor type-1 inhibitor targets
P37173 TGFBR2 TGF-beta receptor type-2 inhibitor targets
P41240 CSK Tyrosine-protein kinase CSK inhibitor targets
P41743 PRKCI Protein kinase C iota type inhibitor targets
P42345 MTOR Serine/threonine-protein kinase mTOR inhibitor targets
P42679 MATK Megakaryocyte-associated tyrosine-protein kinase inhibitor targets
P42680 TEC Tyrosine-protein kinase Tec inhibitor targets
P42681 TXK Tyrosine-protein kinase TXK inhibitor targets
P42684 ABL2 Tyrosine-protein kinase ABL2 inhibitor targets
P42685 FRK Tyrosine-protein kinase FRK inhibitor targets
P43403 ZAP70 Tyrosine-protein kinase ZAP-70 inhibitor targets
P43405 SYK Tyrosine-protein kinase SYK inhibitor targets
P45984 MAPK9 Mitogen-activated protein kinase 9 inhibitor targets
P46734 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 inhibitor targets
P48729 CSNK1A1 Casein kinase I isoform alpha inhibitor targets
P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform inhibitor targets
P49759 CLK1 Dual specificity protein kinase CLK1 inhibitor targets
P49760 CLK2 Dual specificity protein kinase CLK2 inhibitor targets
P49761 CLK3 Dual specificity protein kinase CLK3 inhibitor targets
P49840 GSK3A Glycogen synthase kinase-3 alpha inhibitor targets
P49841 GSK3B Glycogen synthase kinase-3 beta inhibitor targets
P51451 BLK Tyrosine-protein kinase Blk inhibitor targets
P51617 IRAK1 Interleukin-1 receptor-associated kinase 1 inhibitor targets
P51812 RPS6KA3 Ribosomal protein S6 kinase alpha-3 inhibitor targets
P51813 BMX Cytoplasmic tyrosine-protein kinase BMX inhibitor targets
P51955 NEK2 Serine/threonine-protein kinase Nek2 inhibitor targets
P51956 NEK3 Serine/threonine-protein kinase Nek3 inhibitor targets
P51957 NEK4 Serine/threonine-protein kinase Nek4 inhibitor targets
P52333 JAK3 Tyrosine-protein kinase JAK3 inhibitor targets
P52564 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 inhibitor targets
P53350 PLK1 Serine/threonine-protein kinase PLK1 inhibitor targets
P53355 DAPK1 Death-associated protein kinase 1 inhibitor targets
P53667 LIMK1 LIM domain kinase 1 inhibitor targets
P53671 LIMK2 LIM domain kinase 2 inhibitor targets
P53779 MAPK10 Mitogen-activated protein kinase 10 inhibitor targets
P54756 EPHA5 Ephrin type-A receptor 5 inhibitor targets
P54760 EPHB4 Ephrin type-B receptor 4 inhibitor targets
P54762 EPHB1 Ephrin type-B receptor 1 inhibitor targets
P54764 EPHA4 Ephrin type-A receptor 4 inhibitor targets
P57059 SIK1 Serine/threonine-protein kinase SIK1 inhibitor targets
P57078 RIPK4 Receptor-interacting serine/threonine-protein kinase 4 inhibitor targets
P62344 CDPK1 Calcium-dependent protein kinase 1 inhibitor targets
P68400 CSNK2A1 Casein kinase II subunit alpha inhibitor targets
P78356 PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta inhibitor targets
P80192 MAP3K9 Mitogen-activated protein kinase kinase kinase 9 inhibitor targets
P9WI81 pknB Serine/threonine-protein kinase PknB inhibitor targets
Q00532 CDKL1 Cyclin-dependent kinase-like 1 inhibitor targets
Q00536 CDK16 Cyclin-dependent kinase 16 inhibitor targets
Q00537 CDK17 Cyclin-dependent kinase 17 inhibitor targets
Q02156 PRKCE Protein kinase C epsilon type inhibitor targets
Q02763 TEK Angiopoietin-1 receptor inhibitor targets
Q02779 MAP3K10 Mitogen-activated protein kinase kinase kinase 10 inhibitor targets
Q04759 PRKCQ Protein kinase C theta type inhibitor targets
Q04771 ACVR1 Activin receptor type-1 inhibitor targets
Q04912 MST1R Macrophage-stimulating protein receptor inhibitor targets
Q05397 PTK2 Focal adhesion kinase 1 inhibitor targets
Q05655 PRKCD Protein kinase C delta type inhibitor targets
Q05940 SLC18A2 Synaptic vesicular amine transporter inhibitor targets
Q06187 BTK Tyrosine-protein kinase BTK inhibitor targets
Q06418 TYRO3 Tyrosine-protein kinase receptor TYRO3 inhibitor targets
Q07912 TNK2 Activated CDC42 kinase 1 inhibitor targets
Q08345 DDR1 Epithelial discoidin domain-containing receptor 1 inhibitor targets
Q08881 ITK Tyrosine-protein kinase ITK/TSK inhibitor targets
Q12851 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 inhibitor targets
Q12852 MAP3K12 Mitogen-activated protein kinase kinase kinase 12 inhibitor targets
Q12866 MERTK Tyrosine-protein kinase Mer inhibitor targets
Q13131 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 inhibitor targets
Q13153 PAK1 Serine/threonine-protein kinase PAK 1 inhibitor targets
Q13163 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 inhibitor targets
Q13164 MAPK7 Mitogen-activated protein kinase 7 inhibitor targets
Q13177 PAK2 Serine/threonine-protein kinase PAK 2 inhibitor targets
Q13188 STK3 Serine/threonine-protein kinase 3 inhibitor targets
Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 inhibitor targets
Q13237 PRKG2 cGMP-dependent protein kinase 2 inhibitor targets
Q13470 TNK1 Non-receptor tyrosine-protein kinase TNK1 inhibitor targets
Q13523 PRP4K Serine/threonine-protein kinase PRP4 homolog inhibitor targets
Q13546 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 inhibitor targets
Q13554 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta inhibitor targets
Q13555 CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma inhibitor targets
Q13557 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta inhibitor targets
Q13627 DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor targets
Q13873 BMPR2 Bone morphogenetic protein receptor type-2 inhibitor targets
Q13882 PTK6 Protein-tyrosine kinase 6 inhibitor targets
Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 inhibitor targets
Q14164 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon inhibitor targets
Q14289 PTK2B Protein-tyrosine kinase 2-beta inhibitor targets
Q14680 MELK Maternal embryonic leucine zipper kinase inhibitor targets
Q15139 PRKD1 Serine/threonine-protein kinase D1 inhibitor targets
Q15208 STK38 Serine/threonine-protein kinase 38 inhibitor targets
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 inhibitor targets
Q15375 EPHA7 Ephrin type-A receptor 7 inhibitor targets
Q15418 RPS6KA1 Ribosomal protein S6 kinase alpha-1 inhibitor targets
Q15569 TESK1 Dual specificity testis-specific protein kinase 1 inhibitor targets
Q15746 MYLK Myosin light chain kinase, smooth muscle inhibitor targets
Q16288 NTRK3 NT-3 growth factor receptor inhibitor targets
Q16512 PKN1 Serine/threonine-protein kinase N1 inhibitor targets
Q16513 PKN2 Serine/threonine-protein kinase N2 inhibitor targets
Q16539 MAPK14 Mitogen-activated protein kinase 14 inhibitor targets
Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 inhibitor targets
Q16620 NTRK2 BDNF/NT-3 growth factors receptor inhibitor targets
Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform inhibitor targets
Q16832 DDR2 Discoidin domain-containing receptor 2 inhibitor targets
Q2M2I8 AAK1 AP2-associated protein kinase 1 inhibitor targets
Q32MK0 MYLK3 Myosin light chain kinase 3 inhibitor targets
Q52WX2 SBK1 Serine/threonine-protein kinase SBK1 inhibitor targets
Q56UN5 MAP3K19 Mitogen-activated protein kinase kinase kinase 19 inhibitor targets
Q59H18 TNNI3K Serine/threonine-protein kinase TNNI3K inhibitor targets
Q5S007 LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 inhibitor targets
Q6DT37 CDC42BPG Serine/threonine-protein kinase MRCK gamma inhibitor targets
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 inhibitor targets
Q6PHR2 ULK3 Serine/threonine-protein kinase ULK3 inhibitor targets
Q6ZN16 MAP3K15 Mitogen-activated protein kinase kinase kinase 15 inhibitor targets
Q7KZI7 MARK2 Serine/threonine-protein kinase MARK2 inhibitor targets
Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 inhibitor targets
Q7Z460 Q7Z460 CLIP-associating protein 1 inhibitor targets
Q86UE8 TLK2 Serine/threonine-protein kinase tousled-like 2 inhibitor targets
Q86V86 PIM3 Serine/threonine-protein kinase pim-3 inhibitor targets
Q86YV6 MYLK4 Myosin light chain kinase family member 4 inhibitor targets
Q8IU85 CAMK1D Calcium/calmodulin-dependent protein kinase type 1D inhibitor targets
Q8IVH8 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3 inhibitor targets
Q8IW41 MAPKAPK5 MAP kinase-activated protein kinase 5 inhibitor targets
Q8IY84 NIM1K Serine/threonine-protein kinase NIM1 inhibitor targets
Q8IYT8 ULK2 Serine/threonine-protein kinase ULK2 inhibitor targets
Q8N4C8 MINK1 Misshapen-like kinase 1 inhibitor targets
Q8N568 DCLK2 Serine/threonine-protein kinase DCLK2 inhibitor targets
Q8N5S9 CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 inhibitor targets
Q8NEV4 MYO3A Myosin-IIIa inhibitor targets
Q8NFD2 ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1 inhibitor targets
Q8NG66 NEK11 Serine/threonine-protein kinase Nek11 inhibitor targets
Q8NI60 COQ8A Atypical kinase COQ8A, mitochondrial inhibitor targets
Q8TBX8 PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma inhibitor targets
Q8TD08 MAPK15 Mitogen-activated protein kinase 15 inhibitor targets
Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 inhibitor targets
Q8TDR2 STK35 Serine/threonine-protein kinase 35 inhibitor targets
Q8WU08 STK32A Serine/threonine-protein kinase 32A inhibitor targets
Q92772 CDKL2 Cyclin-dependent kinase-like 2 inhibitor targets
Q92918 MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1 inhibitor targets
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 inhibitor targets
Q96D53 COQ8B Atypical kinase COQ8B, mitochondrial inhibitor targets
Q96GD4 AURKB Aurora kinase B inhibitor targets
Q96L34 MARK4 MAP/microtubule affinity-regulating kinase 4 inhibitor targets
Q96NX5 CAMK1G Calcium/calmodulin-dependent protein kinase type 1G inhibitor targets
Q96PY6 NEK1 Serine/threonine-protein kinase Nek1 inhibitor targets
Q96Q40 CDK15 Cyclin-dependent kinase 15 inhibitor targets
Q96RR4 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 inhibitor targets
Q99640 PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase inhibitor targets
Q99759 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 inhibitor targets
Q99808 SLC29A1 Equilibrative nucleoside transporter 1 inhibitor targets
Q9BQI3 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 inhibitor targets
Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 inhibitor targets
Q9BUB5 MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 inhibitor targets
Q9BVS4 RIOK2 Serine/threonine-protein kinase RIO2 inhibitor targets
Q9BXA7 TSSK1B Testis-specific serine/threonine-protein kinase 1 inhibitor targets
Q9BYT3 STK33 Serine/threonine-protein kinase 33 inhibitor targets
Q9C098 DCLK3 Serine/threonine-protein kinase DCLK3 inhibitor targets
Q9H093 NUAK2 NUAK family SNF1-like kinase 2 inhibitor targets
Q9H0K1 SIK2 Serine/threonine-protein kinase SIK2 inhibitor targets
Q9H1R3 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle inhibitor targets
Q9H2G2 SLK STE20-like serine/threonine-protein kinase inhibitor targets
Q9H2K8 TAOK3 Serine/threonine-protein kinase TAO3 inhibitor targets
Q9H2X6 HIPK2 Homeodomain-interacting protein kinase 2 inhibitor targets
Q9H3Y6 SRMS Tyrosine-protein kinase Srms inhibitor targets
Q9H422 HIPK3 Homeodomain-interacting protein kinase 3 inhibitor targets
Q9H4B4 PLK3 Serine/threonine-protein kinase PLK3 inhibitor targets
Q9HAZ1 CLK4 Dual specificity protein kinase CLK4 inhibitor targets
Q9HBH9 MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 inhibitor targets
Q9NQU5 PAK6 Serine/threonine-protein kinase PAK 6 inhibitor targets
Q9NRH2 SNRK SNF-related serine/threonine-protein kinase inhibitor targets
Q9NRP7 STK36 Serine/threonine-protein kinase 36 inhibitor targets
Q9NSY1 BMP2K BMP-2-inducible protein kinase inhibitor targets
Q9NWZ3 IRAK4 Interleukin-1 receptor-associated kinase 4 inhibitor targets
Q9NYL2 MAP3K20 Mitogen-activated protein kinase kinase kinase 20 inhibitor targets
Q9NYY3 PLK2 Serine/threonine-protein kinase PLK2 inhibitor targets
Q9P0L2 MARK1 Serine/threonine-protein kinase MARK1 inhibitor targets
Q9P286 PAK5 Serine/threonine-protein kinase PAK 5 inhibitor targets
Q9P289 STK26 Serine/threonine-protein kinase 26 inhibitor targets
Q9P2K8 EIF2AK4 eIF-2-alpha kinase GCN2 inhibitor targets
Q9UBF8 PI4KB Phosphatidylinositol 4-kinase beta inhibitor targets
Q9UEE5 STK17A Serine/threonine-protein kinase 17A inhibitor targets
Q9UEW8 STK39 STE20/SPS1-related proline-alanine-rich protein kinase inhibitor targets
Q9UF33 EPHA6 Ephrin type-A receptor 6 inhibitor targets
Q9UHD2 TBK1 Serine/threonine-protein kinase TBK1 inhibitor targets
Q9UIK4 DAPK2 Death-associated protein kinase 2 inhibitor targets
Q9UK32 RPS6KA6 Ribosomal protein S6 kinase alpha-6 inhibitor targets
Q9UKE5 TNIK TRAF2 and NCK-interacting protein kinase inhibitor targets
Q9UKI8 TLK1 Serine/threonine-protein kinase tousled-like 1 inhibitor targets
Q9UL54 TAOK2 Serine/threonine-protein kinase TAO2 inhibitor targets
Q9UM73 ALK ALK tyrosine kinase receptor inhibitor targets
Q9UPZ9 CILK1 Serine/threonine-protein kinase ICK inhibitor targets
Q9UQB9 AURKC Aurora kinase C inhibitor targets
Q9UQM7 CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha inhibitor targets
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like inhibitor targets
Q9Y2H9 MAST1 Microtubule-associated serine/threonine-protein kinase 1 inhibitor targets
Q9Y2K2 SIK3 Serine/threonine-protein kinase SIK3 inhibitor targets
Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 inhibitor targets
Q9Y463 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B inhibitor targets
Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 inhibitor targets
Q9Y616 IRAK3 Interleukin-1 receptor-associated kinase 3 inhibitor targets
Q9Y6E0 STK24 Serine/threonine-protein kinase 24 inhibitor targets
Q9Y6R4 MAP3K4 Mitogen-activated protein kinase kinase kinase 4 inhibitor targets
Q9UNQ0 ABCG2 Broad substrate specificity ATP-binding cassette transporter ABCG2 inhibitor transporters
Q2M3G0 Q2M3G0 ATP-binding cassette sub-family B member 5 substrate transporters