Molecule Details
| InChIKey | GKCBAIGFKIBETG-UHFFFAOYSA-N |
|---|---|
| Compound Name | Tetracaine |
| Canonical SMILES | CCCCNc1ccc(C(=O)OCCN(C)C)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.39 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09085 |
|---|---|
| Drug Name | Tetracaine |
| CAS Number | 94-24-6 |
| Groups | approved investigational vet_approved |
| ATC Codes | C05AD02 N01BA03 D04AB06 N01BA53 S01HA03 |
| Description | Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch. |
Categories: Acids, Carbocyclic Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Aminobenzoates Anesthetics Anesthetics for Topical Use Anesthetics, General Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Benzene Derivatives Benzoates Central Nervous System Agents Central Nervous System Depressants Dental Agents Dermatologicals Esters of Aminobenzoic Acid Local Anesthesia Local Anesthetics (Ester) Methemoglobinemia Associated Agents Nervous System Ophthalmologicals Peripheral Nervous System Agents Sensory Organs Sensory System Agents Vasoprotectives para-Aminobenzoates
Cross-references: BindingDB: 50017659 ChEBI: 9468 CHEMBL698 ChemSpider: 5218 Drugs Product Database (DPD): 6788 C07526 D00551 PDB: TE4 PharmGKB: PA451638 PubChem:5411 PubChem:310265012 RxCUI: 10391 Wikipedia: Tetracaine ZINC: ZINC000001530811
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q01118 | SCN7A | Homo sapiens | Human | PF00520 PF24609 PF06512 | 7.2 | IC50 | ChEMBL |
| Q15858 | SCN9A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.6 | IC50 | ChEMBL;BindingDB |
| P21397 | MAOA | Homo sapiens | Human | PF01593 | 6.5 | IC50 | ChEMBL |
| P35498 | SCN1A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.4 | IC50 | ChEMBL;BindingDB |
| Q99250 | SCN2A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.3 | IC50 | ChEMBL;BindingDB |
| Q14524 | SCN5A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.3 | IC50 | ChEMBL;BindingDB |
| Q9UQD0 | SCN8A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.3 | IC50 | ChEMBL;BindingDB |
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 6.2 | Ki | ChEMBL |
| Q9NY46 | SCN3A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.1 | IC50 | ChEMBL;BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.0 | Ki | ChEMBL |