Molecule Details
InChIKeyGHPFQRTVUDXWCC-UHFFFAOYSA-N
Compound Name2-benzyl-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]propan-1-amine
Canonical SMILESCc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)35
Pfam Stratification Cross-Family
Avg pChEMBL6.96
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (35)
Target Gene Organism Category Pfam pChEMBL Type Source
P08069 IGF1R Homo sapiens Human PF00757 PF07714 PF01030 9.0 Ki ChEMBL
P06213 INSR Homo sapiens Human PF00757 PF17870 PF07714 PF01030 8.6 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 8.2 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 8.1 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 8.0 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 7.8 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.7 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 7.6 Ki ChEMBL
Q14012 CAMK1 Homo sapiens Human PF00069 7.5 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 7.4 Ki ChEMBL
P05129 PRKCG Homo sapiens Human PF00130 PF00168 PF00069 PF00433 7.3 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 7.1 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.9 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.7 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.4 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.4 Ki ChEMBL
P31751 AKT2 Homo sapiens Human PF00169 PF00069 PF00433 6.3 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.1 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.1 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.0 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 6.0 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.0 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL