Molecule Details
| InChIKey | GHMKQBWHPQMXSH-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-(3,5-bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide |
| Canonical SMILES | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1C(F)(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.3 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P05412 | JUN | Homo sapiens | Human | PF00170 PF03957 | 7.3 | IC50 | ChEMBL;BindingDB |
| P18846 | ATF1 | Homo sapiens | Human | PF00170 PF02173 | 7.3 | IC50 | ChEMBL;BindingDB |
| P19838 | NFKB1 | Homo sapiens | Human | PF12796 PF00531 PF16179 PF00554 | 7.3 | IC50 | ChEMBL;BindingDB |
| Q00653 | NFKB2 | Homo sapiens | Human | PF00023 PF12796 PF00531 PF16179 PF00554 | 7.3 | IC50 | ChEMBL |
| Q04206 | RELA | Homo sapiens | Human | PF16179 PF00554 | 7.3 | IC50 | ChEMBL |