Molecule Details
InChIKeyGHAZVJQMLWOQLP-UHFFFAOYSA-N
Compound Name1-Pyrazin-2-yl-3-(6-trifluoromethyl-quinolin-4-yl)-urea
Canonical SMILESO=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)17
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (17)
Target Gene Organism Category Pfam pChEMBL Type Source
P49841 GSK3B Homo sapiens Human PF00069 8.4 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.7 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q96KB5 PBK Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.1 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.0 Ki ChEMBL