Molecule Details
InChIKeyGGCSSNBKKAUURC-UHFFFAOYSA-N
Compound NameSufentanil
Canonical SMILESCCC(=O)N(c1ccccc1)C1(COC)CCN(CCc2cccs2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.03
SourceBindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00708
Drug NameSufentanil
CAS Number56030-54-7
Groups approved investigational
ATC Codes N01AH03
DescriptionSufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults...

Categories: Adjuvants, Anesthesia Agents that produce hypertension Analgesics Anesthetics Anesthetics, General Anesthetics, Intravenous Bradycardia-Causing Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Fentanyl and fentanyl analogues High-risk opioids Hypotensive Agents Narcotics Nervous System Neuraxial Anesthetics Opiate Agonists Opioid Agonist Opioid Anesthetics Opioids Opioids, Anilidopiperidine Peripheral Nervous System Agents Phenylpiperidine opioids Piperidines Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
Cross-references: BindingDB: 94503 ChEBI: 9316 CHEMBL658 ChemSpider: 38043 Drugs Product Database (DPD): 12343 Guide to Pharmacology: 3534 IUPHAR: 3534 C08022 D05938 PharmGKB: PA451527 PubChem:41693 PubChem:46504737 RxCUI: 56795 Therapeutic Targets Database: DAP000357 Wikipedia: Sufentanil ZINC: ZINC000000538386
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P35372 OPRM1 Homo sapiens Human PF00001 9.7 Ki BindingDB
P41143 OPRD1 Homo sapiens Human PF00001 7.3 Ki BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 7.1 Ki BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P35372 OPRM1 Mu-type opioid receptor agonist targets
P41143 OPRD1 Delta-type opioid receptor agonist targets
P41145 OPRK1 Kappa-type opioid receptor binder targets