Molecule Details
InChIKeyGFUITADOEPNRML-SJORKVTESA-N
Compound NameTrocade
Canonical SMILESCN1C(=O)N(C[C@H](C(=O)NO)[C@@H](CC2CCCC2)C(=O)N2CCCCC2)C(=O)C1(C)C
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.92
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19468
Drug NameCipemastat
CAS Number190648-49-8
Groups experimental
ATC Codes nan
DescriptionCipemastat is a small molecule drug. The usage of the INN stem '-mastat' in the name indicates that Cipemastat is a matrix metalloproteinase inhibitor. Cipemastat has a monoisotopic molecular weight of 436.27 Da.

Cross-references: BindingDB: 30344 CHEMBL115653 ZINC: ZINC000000600699
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9ULZ9 MMP17 Homo sapiens Human PF00045 PF00413 PF01471 9.5 pIC50 TTD_MultiTarget
P03956 MMP1 Homo sapiens Human PF00045 PF00413 PF01471 8.6 Ki ChEMBL;BindingDB
P45452 MMP13 Homo sapiens Human PF00045 PF00413 PF01471 8.5 Ki ChEMBL;BindingDB
P22894 MMP8 Homo sapiens Human PF00045 PF00413 PF01471 8.4 Ki ChEMBL;BindingDB
P09237 MMP7 Homo sapiens Human PF00413 PF01471 7.7 IC50 ChEMBL
P50281 MMP14 Homo sapiens Human PF11857 PF00045 PF00413 PF01471 7.6 IC50 ChEMBL
P14780 MMP9 Homo sapiens Human PF00040 PF00045 PF00413 7.2 IC50 ChEMBL;BindingDB
P08253 MMP2 Homo sapiens Human PF00040 PF00045 PF00413 6.8 pIC50 TTD_MultiTarget
P08254 MMP3 Homo sapiens Human PF00045 PF00413 PF01471 6.7 IC50 ChEMBL;BindingDB
P78536 ADAM17 Homo sapiens Human PF16698 PF00200 PF13574 6.6 Ki ChEMBL;BindingDB
P18843 nadE Escherichia coli (strain K12) Pathogen PF02540 9.3 pIC50 TTD_MultiTarget
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P03956 MMP1 Interstitial collagenase modulator targets
P22894 MMP8 Neutrophil collagenase modulator targets