Molecule Details
| InChIKey | GESSGPHQVIWQGV-UHFFFAOYSA-N |
|---|---|
| Compound Name | 6-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3-methyl-1-propyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one |
| Canonical SMILES | CCCn1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.53 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 8.1 | IC50 | ChEMBL;BindingDB |
| P54750 | PDE1A | Homo sapiens | Human | PF00233 PF08499 | 6.0 | IC50 | ChEMBL |
| Q01064 | PDE1B | Homo sapiens | Human | PF00233 PF08499 | 6.0 | IC50 | ChEMBL;BindingDB |
| Q14123 | PDE1C | Homo sapiens | Human | PF00233 PF08499 | 6.0 | IC50 | ChEMBL |