Molecule Details
| InChIKey | GEIITDFWTJJONU-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-[(2,6-difluoro-3,5-dimethoxy-N-[3-(1-methylpyrazol-4-yl)-1,7-naphthyridin-6-yl]anilino)methyl]-N,N-dimethylimidazole-1-sulfonamide |
| Canonical SMILES | COc1cc(OC)c(F)c(N(Cc2nccn2S(=O)(=O)N(C)C)c2cc3cc(-c4cnn(C)c4)cnc3cn2)c1F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.42 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11362 | FGFR1 | Homo sapiens | Human | PF07679 PF00047 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |
| P21802 | FGFR2 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.8 | IC50 | ChEMBL;BindingDB |
| P22607 | FGFR3 | Homo sapiens | Human | PF21165 PF07679 PF13927 PF07714 | 7.6 | IC50 | ChEMBL;BindingDB |
| P22455 | FGFR4 | Homo sapiens | Human | PF07679 PF13927 PF07714 | 7.1 | IC50 | ChEMBL;BindingDB |
| P35968 | KDR | Homo sapiens | Human | PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 | 6.8 | IC50 | ChEMBL;BindingDB |