InChIKey	GDLIGKIOYRNHDA-UHFFFAOYSA-N
Compound Name	Clomipramine
Canonical SMILES	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	24
Pfam Stratification	Cross-Family
Avg pChEMBL	7.15
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB01242
Drug Name	Clomipramine
CAS Number	303-49-1
Groups	approved investigational vet_approved
ATC Codes	N06AA04
Description	Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does no...

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Categories: Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Tricyclic Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (strong) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dibenzazepines Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Hypotensive Agents Membrane Transport Modulators Moderate Risk QTc-Prolonging Agents Narrow Therapeutic Index Drugs Nervous System Neurotoxic agents Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Non-Selective Monoamine Reuptake Inhibitors P-glycoprotein inhibitors Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Modulators Serotonin Receptor Antagonists Tertiary amine tricyclic antidepressants Tricyclics and Other Norepinephrine-reuptake Inhibitors

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Cross-references: BindingDB: 77970 ChEBI: 47780 CHEMBL415 ChemSpider: 2699 Drugs Product Database (DPD): 2442 Guide to Pharmacology: 2398 IUPHAR: 2398 C06918 D00811 PDB: CXX PharmGKB: PA449048 PubChem:2801 PubChem:46505157 RxCUI: 2597 Therapeutic Targets Database: DAP000742 Wikipedia: Clomipramine ZINC: ZINC000000020248