Molecule Details
| InChIKey | GBYGWVVFPYTZJX-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5-fluoro-4-(7-fluoro-2,3,3-trimethylindol-5-yl)-N-(5-piperazin-1-yl-2-pyridinyl)pyrimidin-2-amine |
| Canonical SMILES | CC1=Nc2c(F)cc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2C1(C)C |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.0 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P30281 | CCND3 | Homo sapiens | Human | PF02984 PF00134 | 7.4 | IC50 | ChEMBL |
| Q00534 | CDK6 | Homo sapiens | Human | PF00069 | 7.4 | IC50 | ChEMBL;BindingDB |
| P11309 | PIM1 | Homo sapiens | Human | PF00069 | 6.7 | IC50 | ChEMBL;BindingDB |
| P06493 | CDK1 | Homo sapiens | Human | PF00069 | 6.6 | IC50 | ChEMBL;BindingDB |