Molecule Details
InChIKeyGAVRMVQHHVMXFD-UHFFFAOYSA-N
Compound Name2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine
Canonical SMILESN=C(N)c1ccc2[nH]c(-c3cccc(-c4ccccc4)c3O)cc2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Homologous
Avg pChEMBL7.22
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB03159
Drug NameCRA_8696
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 50102780 CHEMBL96433 ChemSpider: 394569 PDB: 696 PubChem:447476 PubChem:46508324 ZINC: ZINC000002047576
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
P03952 KLKB1 Homo sapiens Human PF00024 PF00089 8.7 Ki ChEMBL
P00749 PLAU Homo sapiens Human PF00051 PF00089 8.1 Ki ChEMBL;BindingDB
P00750 PLAT Homo sapiens Human PF00008 PF00039 PF00051 PF00089 7.5 Ki ChEMBL;BindingDB
P00742 F10 Homo sapiens Human PF00008 PF14670 PF00594 PF00089 7.1 Ki ChEMBL;BindingDB
P05981 HPN Homo sapiens Human PF09272 PF00089 7.1 Ki BindingDB
P00747 PLG Homo sapiens Human PF00051 PF00024 PF00089 7.0 Ki ChEMBL;BindingDB
P07477 PRSS1 Homo sapiens Human PF00089 6.9 Ki ChEMBL;BindingDB
P07478 PRSS2 Homo sapiens Human PF00089 6.9 Ki ChEMBL
P35030 PRSS3 Homo sapiens Human PF00089 6.9 Ki ChEMBL
P08709 F7 Homo sapiens Human PF00008 PF14670 PF00594 PF00089 6.8 Ki ChEMBL;BindingDB
P00734 F2 Homo sapiens Human PF00594 PF00051 PF09396 PF00089 6.5 Ki ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P07477 PRSS1 Serine protease 1 binder targets
P00734 F2 Prothrombin inhibitor targets
P00749 PLAU Urokinase-type plasminogen activator inhibitor targets