Molecule Details
| InChIKey | GALWNKLIQPVNFO-UHFFFAOYSA-N |
|---|---|
| Compound Name | Morpholin-4-yl-[3-[1-[2-(oxan-4-yl)ethyl]piperidin-3-yl]-8,8-dioxo-8lambda6-thia-3,4,10-triazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,10,12-pentaen-5-yl]methanone |
| Canonical SMILES | O=C(c1nn(C2CCCN(CCC3CCOCC3)C2)c2c1CS(=O)(=O)c1ncccc1-2)N1CCOCC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.21 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O00329 | PIK3CD | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 7.2 | IC50 | ChEMBL |
| O00459 | PIK3R2 | Homo sapiens | Human | PF16454 PF00620 PF00017 | 7.2 | IC50 | ChEMBL |
| P27986 | PIK3R1 | Homo sapiens | Human | PF16454 PF00620 PF00017 | 7.2 | IC50 | ChEMBL |
| P42336 | PIK3CA | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 7.2 | IC50 | ChEMBL;BindingDB |
| P42338 | PIK3CB | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 7.2 | IC50 | ChEMBL |
| P48736 | PIK3CG | Homo sapiens | Human | PF00454 PF00792 PF00794 PF00613 PF19710 | 7.2 | IC50 | ChEMBL |
| Q8WYR1 | PIK3R5 | Homo sapiens | Human | PF10486 | 7.2 | IC50 | ChEMBL |
| Q92569 | PIK3R3 | Homo sapiens | Human | PF16454 PF00017 | 7.2 | IC50 | ChEMBL |