Molecule Details
InChIKeyFXUAIOOAOAVCGD-WCTZXXKLSA-N
Compound NameSwainsonine
Canonical SMILESO[C@H]1[C@H]2[C@H](O)CCCN2C[C@H]1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.35
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB02034
Drug NameTridolgosir
CAS Number72741-87-8
Groups experimental
ATC Codes nan
DescriptionAn indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Cross-references: BindingDB: 50168995 ChEBI: 9367 CHEMBL371197 ChemSpider: 46788 C10173 PDB: SWA PubChem:51683 PubChem:46506581 Wikipedia: Swainsonine ZINC: ZINC000003875041
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16706 MAN2A1 Homo sapiens Human PF09261 PF07748 PF01074 PF21260 7.4 IC50 BindingDB
O00754 MAN2B1 Homo sapiens Human PF09261 PF17677 PF07748 PF01074 PF21260 7.3 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q16706 MAN2A1 Alpha-mannosidase 2 inhibitor targets