Molecule Details
InChIKeyFVYXIJYOAGAUQK-UHFFFAOYSA-N
Compound NameHonokiol
Canonical SMILESC=CCc1ccc(O)c(-c2ccc(O)c(CC=C)c2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.48
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19283
Drug NameHonokiol
CAS Number35354-74-6
Groups investigational
ATC Codes nan
DescriptionHonokiol is under investigation in clinical trial NCT00966953 (Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.).

Categories: Alkenes Anti-Allergic Agents Anti-Anxiety Agents Anti-Infective Agents Antiarrhythmic agents Antigout Preparations Antimetabolites Antineoplastic Agents Antineoplastic Agents, Phytogenic Antioxidants Antirheumatic Agents Benzene Derivatives Cardiovascular Agents Central Nervous System Agents Central Nervous System Depressants Drugs, Chinese Herbal Enzyme Inhibitors Free Radical Scavengers Gastrointestinal Agents Heterocyclic Compounds, Fused-Ring Hydrocarbons, Acyclic Noxae Plant Extracts Psychotropic Drugs Purines Toxic Actions Tranquilizing Agents
Cross-references: BindingDB: 50157304 ChEBI: 5759 CHEMBL16901 ChemSpider: 65254 C10630 PDB: Y4T RxCUI: 2562546 Wikipedia: Honokiol ZINC: ZINC000000001536
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P34972 CNR2 Homo sapiens Human PF00001 8.2 Ki BindingDB
P21554 CNR1 Homo sapiens Human PF00001 8.2 Ki BindingDB
Q9NTG7 SIRT3 Homo sapiens Human PF02146 6.0 Kd ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P09917 ALOX5 Polyunsaturated fatty acid 5-lipoxygenase inhibitor targets
P23219 PTGS1 Prostaglandin G/H synthase 1 inhibitor targets
P35354 PTGS2 Prostaglandin G/H synthase 2 inhibitor targets