Molecule Details
| InChIKey | FUZYTVDVLBBXDL-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.59 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13978 |
|---|---|
| Drug Name | Selisistat |
| CAS Number | 49843-98-3 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents. |
Categories: Heterocyclic Compounds, Fused-Ring Indoles Sirtuin 1, antagonists & inhibitors
Cross-references: BindingDB: 50178769 ChEBI: 90369 CHEMBL420311 ChemSpider: 4288080
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | inhibitor | targets |