Molecule Details
InChIKeyFTIAKTLRFKSDFR-UHFFFAOYSA-N
Compound Name4-amino-5-cyano-6-ethoxy-N-[(2-sulfamoylphenyl)methyl]pyridine-2-carboxamide
Canonical SMILESCCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1C#N
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.66
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P45983 MAPK8 Homo sapiens Human PF00069 7.9 IC50 ChEMBL;BindingDB
P53779 MAPK10 Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 7.3 IC50 ChEMBL;BindingDB
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.8 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.1 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL