Molecule Details
| InChIKey | FSQKKOOTNAMONP-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.0 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13783 |
|---|---|
| Drug Name | Acemetacin |
| CAS Number | 53164-05-9 |
| Groups | approved |
| ATC Codes | M01AB11 |
| Description | Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin.[A31352] In clinical trials, acemetacin exhibits a better gastric tolerabil... |
Categories: Acetic Acid Derivatives and Related Substances Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antigout Preparations Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Heterocyclic Compounds, Fused-Ring Indoles Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS Peripheral Nervous System Agents Sensory System Agents UGT2B7 substrates
Cross-references: BindingDB: 50336272 ChEBI: 31162 CHEMBL189171 ChemSpider: 1904 D01582 PharmGKB: PA166049184 PubChem:1981 PubChem:347829316 RxCUI: 16695 Wikipedia: Acemetacin ZINC: ZINC000000601272