Molecule Details
InChIKeyFSKFPVLPFLJRQB-UHFFFAOYSA-N
Canonical SMILESCc1ccc(C(=O)C(C)CN2CCCCC2)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Cross-Family
Avg pChEMBL7.12
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06264
Drug NameTolperisone
CAS Number728-88-1
Groups investigational
ATC Codes M03BX04 M02AX06
DescriptionTolperisone is an oral, centrally acting muscle relaxant. Its precise mechanism is not completely understood, though it blocks sodium and calcium channels. It possesses a high affinity for nervous system tissue, reaching highest concentrations in brain stem, spinal cord and peripheral nerves. Based ...

Categories: Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 Substrates Ketones Muscle Relaxants Muscle Relaxants, Centrally Acting Agents Musculo-Skeletal System Neuromuscular Agents Peripheral Nervous System Agents Propiophenones Pyridines Topical Products for Joint and Muscular Pain
Cross-references: BindingDB: 442744 ChEBI: 93835 CHEMBL1076211 ChemSpider: 5310 D08617 RxCUI: 10639 Wikipedia: Tolperisone
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q99720 SIGMAR1 Homo sapiens Human PF04622 8.1 IC50 ChEMBL
P18089 ADRA2B Homo sapiens Human PF00001 6.2 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P05177 CYP1A2 Cytochrome P450 1A2 substrate enzymes
Q9UI33 SCN11A Sodium channel protein type 11 subunit alpha modulator targets