Molecule Details
InChIKeyFONINLXADYUZFI-UHFFFAOYSA-N
Compound Name1-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ol
Canonical SMILESOC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)25
Pfam Stratification Cross-Family
Avg pChEMBL6.52
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (25)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 7.9 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.6 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.9 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.9 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.8 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.6 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.4 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.4 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.3 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.2 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.2 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.2 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.2 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 Ki ChEMBL