Molecule Details
InChIKeyFOMAIMPXVLHOCI-UHFFFAOYSA-N
Compound Name1-(2,6-Dichlorophenyl)-3-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)urea
Canonical SMILESCCN(CC)CCOc1ccc(Nc2cc(NC(=O)Nc3c(Cl)cccc3Cl)ncn2)cc1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)10
Pfam Stratification Cross-Family
Avg pChEMBL6.52
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (10)
Target Gene Organism Category Pfam pChEMBL Type Source
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.2 IC50 ChEMBL;BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 6.8 IC50 ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.6 IC50 ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.6 pIC50 TTD_MultiTarget
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 6.6 pIC50 TTD_MultiTarget
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.5 pIC50 TTD_MultiTarget
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 IC50 ChEMBL;BindingDB
P54760 EPHB4 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.4 IC50 ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 6.0 IC50 ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 IC50 ChEMBL;BindingDB