5-(3-(5-(1-Piperidinylmethyl)-1H-indol-2-yl)-1H-indazol-6-yl)-2H-1,2,3-triazole-4-methanol — MultiTargetDB

Molecule Details

InChIKey	`FNWHPLLNMLOZTL-UHFFFAOYSA-N`
Compound Name	5-(3-(5-(1-Piperidinylmethyl)-1H-indol-2-yl)-1H-indazol-6-yl)-2H-1,2,3-triazole-4-methanol
Canonical SMILES	`OCc1n[nH]nc1-c1ccc2c(-c3cc4cc(CN5CCCCC5)ccc4[nH]3)n[nH]c2c1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	8.01
Source	BindingDB;ChEMBL

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB07213
Drug Name	(5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 12131 CHEMBL374713 ChemSpider: 22376375 PDB: 710 PubChem:16058617 PubChem:99443684 ZINC: ZINC000014949271

Target Activities (3)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O14757	CHEK1	Homo sapiens	Human	PF00069	9.5	IC50	ChEMBL;BindingDB
P50613	CDK7	Homo sapiens	Human	PF00069	7.2	IC50	ChEMBL
P51946	CCNH	Homo sapiens	Human	PF16899 PF00134	7.2	IC50	BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
O14757	CHEK1	Serine/threonine-protein kinase Chk1	binder	targets