N-(4-chloro-2-methyl-3-pyridinyl)-2-[[6-(2-hydroxyethylamino)-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

InChIKey	`FNEDDGRJWXWDNZ-UHFFFAOYSA-N`
Compound Name	N-(4-chloro-2-methyl-3-pyridinyl)-2-[[6-(2-hydroxyethylamino)-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
Canonical SMILES	`Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)n1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	7.18
Source	BindingDB;ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	8.3	IC50	ChEMBL;BindingDB
P14867	GABRA1	Homo sapiens	Human	PF02931 PF02932	8.3	IC50	BindingDB
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	6.5	IC50	ChEMBL;BindingDB
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	6.3	IC50	ChEMBL;BindingDB
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	6.3	IC50	BindingDB