Molecule Details
InChIKeyFNBXDBIYRAPDPI-BHVANESWSA-N
Compound NameLisaftoclax
Canonical SMILESO=C(NS(=O)(=O)c1ccc(NC[C@H]2COCCO2)c([N+](=O)[O-])c1)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CC4(CCC4)CC3)CC2)cc1Oc1cnc2[nH]ccc2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.46
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB18054
Drug NameLisaftoclax
CAS Number2180923-05-9
Groups investigational
ATC Codes nan
DescriptionLisaftoclax is a novel, orally active, selective and potent BCL-2 inhibitor
Categories: Benzene Derivatives Nitro Compounds
Cross-references: ChemSpider: 103835872
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P10415 BCL2 Homo sapiens Human PF00452 PF02180 8.7 IC50 ChEMBL;BindingDB
O43521 BCL2L11 Homo sapiens Human PF08945 PF06773 8.5 IC50 BindingDB
Q07817 BCL2L1 Homo sapiens Human PF00452 PF02180 8.2 IC50 BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P10415 BCL2 Apoptosis regulator Bcl-2 inhibitor targets