Molecule Details
InChIKeyFMPKTXNCNJCHCC-UHFFFAOYSA-N
Compound NameN-Benzyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine
Canonical SMILESc1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)25
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (25)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 8.5 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 8.4 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.3 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 8.1 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.5 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.2 Ki ChEMBL
P17612 PRKACA Homo sapiens Human PF00069 7.2 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.0 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.0 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.7 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.6 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.5 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.3 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.2 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.1 Ki ChEMBL
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
Q9Y243 AKT3 Homo sapiens Human PF00169 PF00069 PF00433 6.1 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 6.0 Ki ChEMBL
P31749 AKT1 Homo sapiens Human PF00169 PF00069 PF00433 6.0 Ki ChEMBL