Molecule Details
| InChIKey | FLMRVDLSUJPCPS-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-methyl-2-[1-[[(5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)amino]methyl]-2-azabicyclo[2.1.1]hexan-2-yl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide |
| Canonical SMILES | CNC(=O)c1sc(N2CC3CC2(CNC(=O)c2c[nH]c4ncc(C)cc24)C3)nc1C(F)(F)F |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.43 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 8.4 | IC50 | ChEMBL;BindingDB |
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 7.9 | IC50 | ChEMBL;BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 6.0 | IC50 | ChEMBL;BindingDB |