Molecule Details
InChIKeyFLBNLJLONKAPLR-DQSJHHFOSA-N
Canonical SMILESCCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)31
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (31)
Target Gene Organism Category Pfam pChEMBL Type Source
Q96GD4 AURKB Homo sapiens Human PF00069 8.5 IC50 ChEMBL;BindingDB
P36507 MAP2K2 Homo sapiens Human PF00069 8.4 IC50 ChEMBL;BindingDB
Q9UQB9 AURKC Homo sapiens Human PF00069 7.8 IC50 ChEMBL
O76039 CDKL5 Homo sapiens Human PF00069 7.7 Kd ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
Q02750 MAP2K1 Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P07947 YES1 Homo sapiens Human PF07714 PF00017 PF00018 7.0 Kd ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 7.0 Kd ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Kd ChEMBL
O94804 STK10 Homo sapiens Human PF00069 PF12474 6.9 Kd ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.8 Kd ChEMBL
Q13163 MAP2K5 Homo sapiens Human PF00564 PF00069 6.8 Kd ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.7 Kd ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.6 Kd ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.5 Kd ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.4 Kd ChEMBL
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.4 Kd ChEMBL
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 6.3 Kd ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.3 Kd ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.2 Kd ChEMBL
Q6PHR2 ULK3 Homo sapiens Human PF04212 PF00069 6.2 Kd ChEMBL
O95835 LATS1 Homo sapiens Human PF00069 PF00433 PF00627 6.2 Kd ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Kd ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.1 Kd ChEMBL
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.1 Kd ChEMBL
Q15418 RPS6KA1 Homo sapiens Human PF00069 PF00433 6.1 Kd ChEMBL
Q92918 MAP4K1 Homo sapiens Human PF00780 PF00069 6.1 Kd ChEMBL
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Kd ChEMBL
P42680 TEC Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.0 Kd ChEMBL
Q00526 CDK3 Homo sapiens Human PF00069 6.0 Kd ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.0 Kd ChEMBL